此次,塞门扎撤回的4篇论文均发表在PNAS上,它们分别是: 1. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells 2. Mutual antagonism between hypoxia-inducible factors 1αand 2αregulates oxygen sensing and cardio-respiratory homeostasis 3. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells 4. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
塞门扎团队在指出所担忧的数据后,还表示,“我们认为,该文件的总体结论仍然有效,但由于对该数字的潜在担忧,我们正在撤回这项工作。现在我们已经进行了确认性实验,结果可以在bioRxiv上发布的预印本文章中找到,文章题为Homeostatic responses to hypoxia by the carotid
body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α。对于给您带来的不便,我们深表歉意。”
据科睿唯安的Web of Science数据统计,这些论文总共被引用了750多次,而从1998年到2013年这段时间,塞门扎是NIH科研项目拨款的首席研究员,拨款总额超过900万美元。
以他在2013年发表于《癌症研究》(Cancer Research)上的一篇名为“Collagen
prolyl hydroxylases are essential for breast cancer metastasis”的论文为例,这篇文章有多处图像被指出高度相似,有复制粘贴的嫌疑,有人直言这些图像结果“比预期的要相似得多”。
2013年发表于《癌症研究》的论文,截图来源:pubpeer.com
被质疑的图像:图1B,图片来源pubpeer.com
2021年,塞门扎发表在《细胞·报告》(Cell Reports)上的“HIF-1
recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast
cancer stem cells”论文也同样受到许多科研人员的质疑。
1. Nobel
Prize winner Gregg Semenza retracts four papers – Retraction Watch2. Gregg L. Semenza - Wikipedia3. Site-selective
enzymatic C‒H amidation for synthesis of diverse lactams | Science4. Nobel
winner retracts paper from Science – Retraction Watch5. PubPeer - Search
publications and join the conversation.6. Activation
of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected
cell lines and primary adult T-cell leukaemia cells | Biochemical Journal |
Portland Press7. PubPeer
- Collagen prolyl hydroxylases are essential for breast cancer...8. PubPeer
- HIF-1 recruits NANOG as a coactivator for TERT gene transcri...源创论坛 | 基因编辑技术新进展及其在心血管领域的应用